A study of the association between the ADAM12 and SH3PXD2A (SH3MD1 ) genes and Alzheimer's disease
Identifieur interne : 007A72 ( Main/Exploration ); précédent : 007A71; suivant : 007A73A study of the association between the ADAM12 and SH3PXD2A (SH3MD1 ) genes and Alzheimer's disease
Auteurs : Geoffroy Laumet [France] ; Vincent Petitprez [France] ; Adeline Sillaire [France] ; Anne-Marie Ayral [France] ; Franck Hansmannel [France] ; Julien Chapuis [France] ; Didier Hannequin [France] ; Florence Pasquier [France] ; Elio Scarpini [Italie] ; Daniela Galimberti [Italie] ; Corinne Lendon [Australie] ; Dominique Campion [France] ; Philippe Amouyel [France] ; Jean-Charles Lambert [France]Source :
- Neuroscience letters [ 0304-3940 ] ; 2010.
Descripteurs français
- Pascal (Inist)
English descriptors
- KwdEn :
Abstract
Several observations suggest that neurotoxicity in Alzheimer's disease (AD) can be partly attributed to β-amyloid (Aβ) and senile plaques. Recent work has suggested that the FISH (five SH3 domains) adapter protein and ADAM12 (a disintegrin and metalloprotease) may mediate the neurotoxic effect of Aβ. Both genes are located on chromosome 10, within a region linked to AD (for SH3PXD2A) or nearby (for ADAM12). A recent study reported a statistically significant interaction between 2 variants of these genes (rs3740473 for SH3PXD2A and rs11244787 for ADAM12) with respect to the risk of developing AD. With a view to replicating this observation, we genotyped the two SNPs in four European case-control cohorts of Caucasian origin (1913 cases and 1468 controls) but were unable to confirm the initial results.
Affiliations:
Links toward previous steps (curation, corpus...)
- to stream PascalFrancis, to step Corpus: 002932
- to stream PascalFrancis, to step Curation: 003651
- to stream PascalFrancis, to step Checkpoint: 002649
- to stream Main, to step Merge: 008117
- to stream Main, to step Curation: 007A72
Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en" level="a">A study of the association between the ADAM12 and SH3PXD2A (SH3MD1 ) genes and Alzheimer's disease</title><author><name sortKey="Laumet, Geoffroy" sort="Laumet, Geoffroy" uniqKey="Laumet G" first="Geoffroy" last="Laumet">Geoffroy Laumet</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>INSERM, U744, Université de Lille 2, Institut Pasteur de Lille, BP 245. 1, rue du professeur Calmette</s1><s2>59019 Lille</s2><s3>FRA</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>13 aut.</sZ><sZ>14 aut.</sZ></inist:fA14><country>France</country><wicri:noRegion>59019 Lille</wicri:noRegion><wicri:noRegion>rue du professeur Calmette</wicri:noRegion><wicri:noRegion>59019 Lille</wicri:noRegion></affiliation></author><author><name sortKey="Petitprez, Vincent" sort="Petitprez, Vincent" uniqKey="Petitprez V" first="Vincent" last="Petitprez">Vincent Petitprez</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>INSERM, U744, Université de Lille 2, Institut Pasteur de Lille, BP 245. 1, rue du professeur Calmette</s1><s2>59019 Lille</s2><s3>FRA</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>13 aut.</sZ><sZ>14 aut.</sZ></inist:fA14><country>France</country><wicri:noRegion>59019 Lille</wicri:noRegion><wicri:noRegion>rue du professeur Calmette</wicri:noRegion><wicri:noRegion>59019 Lille</wicri:noRegion></affiliation></author><author><name sortKey="Sillaire, Adeline" sort="Sillaire, Adeline" uniqKey="Sillaire A" first="Adeline" last="Sillaire">Adeline Sillaire</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>INSERM, U744, Université de Lille 2, Institut Pasteur de Lille, BP 245. 1, rue du professeur Calmette</s1><s2>59019 Lille</s2><s3>FRA</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>13 aut.</sZ><sZ>14 aut.</sZ></inist:fA14><country>France</country><wicri:noRegion>59019 Lille</wicri:noRegion><wicri:noRegion>rue du professeur Calmette</wicri:noRegion><wicri:noRegion>59019 Lille</wicri:noRegion></affiliation></author><author><name sortKey="Ayral, Anne Marie" sort="Ayral, Anne Marie" uniqKey="Ayral A" first="Anne-Marie" last="Ayral">Anne-Marie Ayral</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>INSERM, U744, Université de Lille 2, Institut Pasteur de Lille, BP 245. 1, rue du professeur Calmette</s1><s2>59019 Lille</s2><s3>FRA</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>13 aut.</sZ><sZ>14 aut.</sZ></inist:fA14><country>France</country><wicri:noRegion>59019 Lille</wicri:noRegion><wicri:noRegion>rue du professeur Calmette</wicri:noRegion><wicri:noRegion>59019 Lille</wicri:noRegion></affiliation></author><author><name sortKey="Hansmannel, Franck" sort="Hansmannel, Franck" uniqKey="Hansmannel F" first="Franck" last="Hansmannel">Franck Hansmannel</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>INSERM, U744, Université de Lille 2, Institut Pasteur de Lille, BP 245. 1, rue du professeur Calmette</s1><s2>59019 Lille</s2><s3>FRA</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>13 aut.</sZ><sZ>14 aut.</sZ></inist:fA14><country>France</country><wicri:noRegion>59019 Lille</wicri:noRegion><wicri:noRegion>rue du professeur Calmette</wicri:noRegion><wicri:noRegion>59019 Lille</wicri:noRegion></affiliation></author><author><name sortKey="Chapuis, Julien" sort="Chapuis, Julien" uniqKey="Chapuis J" first="Julien" last="Chapuis">Julien Chapuis</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>INSERM, U744, Université de Lille 2, Institut Pasteur de Lille, BP 245. 1, rue du professeur Calmette</s1><s2>59019 Lille</s2><s3>FRA</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>13 aut.</sZ><sZ>14 aut.</sZ></inist:fA14><country>France</country><wicri:noRegion>59019 Lille</wicri:noRegion><wicri:noRegion>rue du professeur Calmette</wicri:noRegion><wicri:noRegion>59019 Lille</wicri:noRegion></affiliation></author><author><name sortKey="Hannequin, Didier" sort="Hannequin, Didier" uniqKey="Hannequin D" first="Didier" last="Hannequin">Didier Hannequin</name><affiliation wicri:level="1"><inist:fA14 i1="02"><s1>INSERM, U614, Faculty of Medicine, IFRMP</s1><s2>76000 Rouen</s2><s3>FRA</s3><sZ>7 aut.</sZ><sZ>12 aut.</sZ></inist:fA14><country>France</country><wicri:noRegion>76000 Rouen</wicri:noRegion><wicri:noRegion>IFRMP</wicri:noRegion><wicri:noRegion>76000 Rouen</wicri:noRegion></affiliation></author><author><name sortKey="Pasquier, Florence" sort="Pasquier, Florence" uniqKey="Pasquier F" first="Florence" last="Pasquier">Florence Pasquier</name><affiliation wicri:level="1"><inist:fA14 i1="03"><s1>EA2391, Department of Neurology, Memory Clinic, Lille University Medical Center, Hôpital Roger Salengro, rue du professeur Emile Laine</s1><s2>59037 Lille</s2><s3>FRA</s3><sZ>8 aut.</sZ></inist:fA14><country>France</country><wicri:noRegion>59037 Lille</wicri:noRegion><wicri:noRegion>rue du professeur Emile Laine</wicri:noRegion><wicri:noRegion>59037 Lille</wicri:noRegion></affiliation></author><author><name sortKey="Scarpini, Elio" sort="Scarpini, Elio" uniqKey="Scarpini E" first="Elio" last="Scarpini">Elio Scarpini</name><affiliation wicri:level="3"><inist:fA14 i1="04"><s1>Department of Neurological Sciences, University of Milan, Fondazione Ospedale Maggiore Policlinico</s1><s2>Milan</s2><s3>ITA</s3><sZ>9 aut.</sZ><sZ>10 aut.</sZ></inist:fA14><country>Italie</country><placeName><settlement type="city">Milan</settlement><region nuts="2">Lombardie</region></placeName></affiliation></author><author><name sortKey="Galimberti, Daniela" sort="Galimberti, Daniela" uniqKey="Galimberti D" first="Daniela" last="Galimberti">Daniela Galimberti</name><affiliation wicri:level="3"><inist:fA14 i1="04"><s1>Department of Neurological Sciences, University of Milan, Fondazione Ospedale Maggiore Policlinico</s1><s2>Milan</s2><s3>ITA</s3><sZ>9 aut.</sZ><sZ>10 aut.</sZ></inist:fA14><country>Italie</country><placeName><settlement type="city">Milan</settlement><region nuts="2">Lombardie</region></placeName></affiliation></author><author><name sortKey="Lendon, Corinne" sort="Lendon, Corinne" uniqKey="Lendon C" first="Corinne" last="Lendon">Corinne Lendon</name><affiliation wicri:level="1"><inist:fA14 i1="05"><s1>Molecular Psychiatry Group, Queensland Institute of Medical Research, PO Royal Brisbane Hospital Queensland</s1><s2>4029 Brisbane</s2><s3>AUS</s3><sZ>11 aut.</sZ></inist:fA14><country>Australie</country><wicri:noRegion>4029 Brisbane</wicri:noRegion></affiliation></author><author><name sortKey="Campion, Dominique" sort="Campion, Dominique" uniqKey="Campion D" first="Dominique" last="Campion">Dominique Campion</name><affiliation wicri:level="1"><inist:fA14 i1="02"><s1>INSERM, U614, Faculty of Medicine, IFRMP</s1><s2>76000 Rouen</s2><s3>FRA</s3><sZ>7 aut.</sZ><sZ>12 aut.</sZ></inist:fA14><country>France</country><wicri:noRegion>76000 Rouen</wicri:noRegion><wicri:noRegion>IFRMP</wicri:noRegion><wicri:noRegion>76000 Rouen</wicri:noRegion></affiliation></author><author><name sortKey="Amouyel, Philippe" sort="Amouyel, Philippe" uniqKey="Amouyel P" first="Philippe" last="Amouyel">Philippe Amouyel</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>INSERM, U744, Université de Lille 2, Institut Pasteur de Lille, BP 245. 1, rue du professeur Calmette</s1><s2>59019 Lille</s2><s3>FRA</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>13 aut.</sZ><sZ>14 aut.</sZ></inist:fA14><country>France</country><wicri:noRegion>59019 Lille</wicri:noRegion><wicri:noRegion>rue du professeur Calmette</wicri:noRegion><wicri:noRegion>59019 Lille</wicri:noRegion></affiliation></author><author><name sortKey="Lambert, Jean Charles" sort="Lambert, Jean Charles" uniqKey="Lambert J" first="Jean-Charles" last="Lambert">Jean-Charles Lambert</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>INSERM, U744, Université de Lille 2, Institut Pasteur de Lille, BP 245. 1, rue du professeur Calmette</s1><s2>59019 Lille</s2><s3>FRA</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>13 aut.</sZ><sZ>14 aut.</sZ></inist:fA14><country>France</country><wicri:noRegion>59019 Lille</wicri:noRegion><wicri:noRegion>rue du professeur Calmette</wicri:noRegion><wicri:noRegion>59019 Lille</wicri:noRegion></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">INIST</idno><idno type="inist">10-0041243</idno><date when="2010">2010</date><idno type="stanalyst">PASCAL 10-0041243 INIST</idno><idno type="RBID">Pascal:10-0041243</idno><idno type="wicri:Area/PascalFrancis/Corpus">002932</idno><idno type="wicri:Area/PascalFrancis/Curation">003651</idno><idno type="wicri:Area/PascalFrancis/Checkpoint">002649</idno><idno type="wicri:explorRef" wicri:stream="PascalFrancis" wicri:step="Checkpoint">002649</idno><idno type="wicri:doubleKey">0304-3940:2010:Laumet G:a:study:of</idno><idno type="wicri:Area/Main/Merge">008117</idno><idno type="wicri:Area/Main/Curation">007A72</idno><idno type="wicri:Area/Main/Exploration">007A72</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a">A study of the association between the ADAM12 and SH3PXD2A (SH3MD1 ) genes and Alzheimer's disease</title><author><name sortKey="Laumet, Geoffroy" sort="Laumet, Geoffroy" uniqKey="Laumet G" first="Geoffroy" last="Laumet">Geoffroy Laumet</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>INSERM, U744, Université de Lille 2, Institut Pasteur de Lille, BP 245. 1, rue du professeur Calmette</s1><s2>59019 Lille</s2><s3>FRA</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>13 aut.</sZ><sZ>14 aut.</sZ></inist:fA14><country>France</country><wicri:noRegion>59019 Lille</wicri:noRegion><wicri:noRegion>rue du professeur Calmette</wicri:noRegion><wicri:noRegion>59019 Lille</wicri:noRegion></affiliation></author><author><name sortKey="Petitprez, Vincent" sort="Petitprez, Vincent" uniqKey="Petitprez V" first="Vincent" last="Petitprez">Vincent Petitprez</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>INSERM, U744, Université de Lille 2, Institut Pasteur de Lille, BP 245. 1, rue du professeur Calmette</s1><s2>59019 Lille</s2><s3>FRA</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>13 aut.</sZ><sZ>14 aut.</sZ></inist:fA14><country>France</country><wicri:noRegion>59019 Lille</wicri:noRegion><wicri:noRegion>rue du professeur Calmette</wicri:noRegion><wicri:noRegion>59019 Lille</wicri:noRegion></affiliation></author><author><name sortKey="Sillaire, Adeline" sort="Sillaire, Adeline" uniqKey="Sillaire A" first="Adeline" last="Sillaire">Adeline Sillaire</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>INSERM, U744, Université de Lille 2, Institut Pasteur de Lille, BP 245. 1, rue du professeur Calmette</s1><s2>59019 Lille</s2><s3>FRA</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>13 aut.</sZ><sZ>14 aut.</sZ></inist:fA14><country>France</country><wicri:noRegion>59019 Lille</wicri:noRegion><wicri:noRegion>rue du professeur Calmette</wicri:noRegion><wicri:noRegion>59019 Lille</wicri:noRegion></affiliation></author><author><name sortKey="Ayral, Anne Marie" sort="Ayral, Anne Marie" uniqKey="Ayral A" first="Anne-Marie" last="Ayral">Anne-Marie Ayral</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>INSERM, U744, Université de Lille 2, Institut Pasteur de Lille, BP 245. 1, rue du professeur Calmette</s1><s2>59019 Lille</s2><s3>FRA</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>13 aut.</sZ><sZ>14 aut.</sZ></inist:fA14><country>France</country><wicri:noRegion>59019 Lille</wicri:noRegion><wicri:noRegion>rue du professeur Calmette</wicri:noRegion><wicri:noRegion>59019 Lille</wicri:noRegion></affiliation></author><author><name sortKey="Hansmannel, Franck" sort="Hansmannel, Franck" uniqKey="Hansmannel F" first="Franck" last="Hansmannel">Franck Hansmannel</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>INSERM, U744, Université de Lille 2, Institut Pasteur de Lille, BP 245. 1, rue du professeur Calmette</s1><s2>59019 Lille</s2><s3>FRA</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>13 aut.</sZ><sZ>14 aut.</sZ></inist:fA14><country>France</country><wicri:noRegion>59019 Lille</wicri:noRegion><wicri:noRegion>rue du professeur Calmette</wicri:noRegion><wicri:noRegion>59019 Lille</wicri:noRegion></affiliation></author><author><name sortKey="Chapuis, Julien" sort="Chapuis, Julien" uniqKey="Chapuis J" first="Julien" last="Chapuis">Julien Chapuis</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>INSERM, U744, Université de Lille 2, Institut Pasteur de Lille, BP 245. 1, rue du professeur Calmette</s1><s2>59019 Lille</s2><s3>FRA</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>13 aut.</sZ><sZ>14 aut.</sZ></inist:fA14><country>France</country><wicri:noRegion>59019 Lille</wicri:noRegion><wicri:noRegion>rue du professeur Calmette</wicri:noRegion><wicri:noRegion>59019 Lille</wicri:noRegion></affiliation></author><author><name sortKey="Hannequin, Didier" sort="Hannequin, Didier" uniqKey="Hannequin D" first="Didier" last="Hannequin">Didier Hannequin</name><affiliation wicri:level="1"><inist:fA14 i1="02"><s1>INSERM, U614, Faculty of Medicine, IFRMP</s1><s2>76000 Rouen</s2><s3>FRA</s3><sZ>7 aut.</sZ><sZ>12 aut.</sZ></inist:fA14><country>France</country><wicri:noRegion>76000 Rouen</wicri:noRegion><wicri:noRegion>IFRMP</wicri:noRegion><wicri:noRegion>76000 Rouen</wicri:noRegion></affiliation></author><author><name sortKey="Pasquier, Florence" sort="Pasquier, Florence" uniqKey="Pasquier F" first="Florence" last="Pasquier">Florence Pasquier</name><affiliation wicri:level="1"><inist:fA14 i1="03"><s1>EA2391, Department of Neurology, Memory Clinic, Lille University Medical Center, Hôpital Roger Salengro, rue du professeur Emile Laine</s1><s2>59037 Lille</s2><s3>FRA</s3><sZ>8 aut.</sZ></inist:fA14><country>France</country><wicri:noRegion>59037 Lille</wicri:noRegion><wicri:noRegion>rue du professeur Emile Laine</wicri:noRegion><wicri:noRegion>59037 Lille</wicri:noRegion></affiliation></author><author><name sortKey="Scarpini, Elio" sort="Scarpini, Elio" uniqKey="Scarpini E" first="Elio" last="Scarpini">Elio Scarpini</name><affiliation wicri:level="3"><inist:fA14 i1="04"><s1>Department of Neurological Sciences, University of Milan, Fondazione Ospedale Maggiore Policlinico</s1><s2>Milan</s2><s3>ITA</s3><sZ>9 aut.</sZ><sZ>10 aut.</sZ></inist:fA14><country>Italie</country><placeName><settlement type="city">Milan</settlement><region nuts="2">Lombardie</region></placeName></affiliation></author><author><name sortKey="Galimberti, Daniela" sort="Galimberti, Daniela" uniqKey="Galimberti D" first="Daniela" last="Galimberti">Daniela Galimberti</name><affiliation wicri:level="3"><inist:fA14 i1="04"><s1>Department of Neurological Sciences, University of Milan, Fondazione Ospedale Maggiore Policlinico</s1><s2>Milan</s2><s3>ITA</s3><sZ>9 aut.</sZ><sZ>10 aut.</sZ></inist:fA14><country>Italie</country><placeName><settlement type="city">Milan</settlement><region nuts="2">Lombardie</region></placeName></affiliation></author><author><name sortKey="Lendon, Corinne" sort="Lendon, Corinne" uniqKey="Lendon C" first="Corinne" last="Lendon">Corinne Lendon</name><affiliation wicri:level="1"><inist:fA14 i1="05"><s1>Molecular Psychiatry Group, Queensland Institute of Medical Research, PO Royal Brisbane Hospital Queensland</s1><s2>4029 Brisbane</s2><s3>AUS</s3><sZ>11 aut.</sZ></inist:fA14><country>Australie</country><wicri:noRegion>4029 Brisbane</wicri:noRegion></affiliation></author><author><name sortKey="Campion, Dominique" sort="Campion, Dominique" uniqKey="Campion D" first="Dominique" last="Campion">Dominique Campion</name><affiliation wicri:level="1"><inist:fA14 i1="02"><s1>INSERM, U614, Faculty of Medicine, IFRMP</s1><s2>76000 Rouen</s2><s3>FRA</s3><sZ>7 aut.</sZ><sZ>12 aut.</sZ></inist:fA14><country>France</country><wicri:noRegion>76000 Rouen</wicri:noRegion><wicri:noRegion>IFRMP</wicri:noRegion><wicri:noRegion>76000 Rouen</wicri:noRegion></affiliation></author><author><name sortKey="Amouyel, Philippe" sort="Amouyel, Philippe" uniqKey="Amouyel P" first="Philippe" last="Amouyel">Philippe Amouyel</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>INSERM, U744, Université de Lille 2, Institut Pasteur de Lille, BP 245. 1, rue du professeur Calmette</s1><s2>59019 Lille</s2><s3>FRA</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>13 aut.</sZ><sZ>14 aut.</sZ></inist:fA14><country>France</country><wicri:noRegion>59019 Lille</wicri:noRegion><wicri:noRegion>rue du professeur Calmette</wicri:noRegion><wicri:noRegion>59019 Lille</wicri:noRegion></affiliation></author><author><name sortKey="Lambert, Jean Charles" sort="Lambert, Jean Charles" uniqKey="Lambert J" first="Jean-Charles" last="Lambert">Jean-Charles Lambert</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>INSERM, U744, Université de Lille 2, Institut Pasteur de Lille, BP 245. 1, rue du professeur Calmette</s1><s2>59019 Lille</s2><s3>FRA</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>13 aut.</sZ><sZ>14 aut.</sZ></inist:fA14><country>France</country><wicri:noRegion>59019 Lille</wicri:noRegion><wicri:noRegion>rue du professeur Calmette</wicri:noRegion><wicri:noRegion>59019 Lille</wicri:noRegion></affiliation></author></analytic><series><title level="j" type="main">Neuroscience letters</title><title level="j" type="abbreviated">Neurosci. lett.</title><idno type="ISSN">0304-3940</idno><imprint><date when="2010">2010</date></imprint></series></biblStruct></sourceDesc><seriesStmt><title level="j" type="main">Neuroscience letters</title><title level="j" type="abbreviated">Neurosci. lett.</title><idno type="ISSN">0304-3940</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Alzheimer disease</term><term>Polymorphism</term></keywords><keywords scheme="Pascal" xml:lang="fr"><term>Polymorphisme</term><term>Démence d'Alzheimer</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Several observations suggest that neurotoxicity in Alzheimer's disease (AD) can be partly attributed to β-amyloid (Aβ) and senile plaques. Recent work has suggested that the FISH (five SH3 domains) adapter protein and ADAM12 (a disintegrin and metalloprotease) may mediate the neurotoxic effect of Aβ. Both genes are located on chromosome 10, within a region linked to AD (for SH3PXD2A) or nearby (for ADAM12). A recent study reported a statistically significant interaction between 2 variants of these genes (rs3740473 for SH3PXD2A and rs11244787 for ADAM12) with respect to the risk of developing AD. With a view to replicating this observation, we genotyped the two SNPs in four European case-control cohorts of Caucasian origin (1913 cases and 1468 controls) but were unable to confirm the initial results.</div></front></TEI><affiliations><list><country><li>Australie</li><li>France</li><li>Italie</li></country><region><li>Lombardie</li></region><settlement><li>Milan</li></settlement></list><tree><country name="France"><noRegion><name sortKey="Laumet, Geoffroy" sort="Laumet, Geoffroy" uniqKey="Laumet G" first="Geoffroy" last="Laumet">Geoffroy Laumet</name></noRegion><name sortKey="Amouyel, Philippe" sort="Amouyel, Philippe" uniqKey="Amouyel P" first="Philippe" last="Amouyel">Philippe Amouyel</name><name sortKey="Ayral, Anne Marie" sort="Ayral, Anne Marie" uniqKey="Ayral A" first="Anne-Marie" last="Ayral">Anne-Marie Ayral</name><name sortKey="Campion, Dominique" sort="Campion, Dominique" uniqKey="Campion D" first="Dominique" last="Campion">Dominique Campion</name><name sortKey="Chapuis, Julien" sort="Chapuis, Julien" uniqKey="Chapuis J" first="Julien" last="Chapuis">Julien Chapuis</name><name sortKey="Hannequin, Didier" sort="Hannequin, Didier" uniqKey="Hannequin D" first="Didier" last="Hannequin">Didier Hannequin</name><name sortKey="Hansmannel, Franck" sort="Hansmannel, Franck" uniqKey="Hansmannel F" first="Franck" last="Hansmannel">Franck Hansmannel</name><name sortKey="Lambert, Jean Charles" sort="Lambert, Jean Charles" uniqKey="Lambert J" first="Jean-Charles" last="Lambert">Jean-Charles Lambert</name><name sortKey="Pasquier, Florence" sort="Pasquier, Florence" uniqKey="Pasquier F" first="Florence" last="Pasquier">Florence Pasquier</name><name sortKey="Petitprez, Vincent" sort="Petitprez, Vincent" uniqKey="Petitprez V" first="Vincent" last="Petitprez">Vincent Petitprez</name><name sortKey="Sillaire, Adeline" sort="Sillaire, Adeline" uniqKey="Sillaire A" first="Adeline" last="Sillaire">Adeline Sillaire</name></country><country name="Italie"><region name="Lombardie"><name sortKey="Scarpini, Elio" sort="Scarpini, Elio" uniqKey="Scarpini E" first="Elio" last="Scarpini">Elio Scarpini</name></region><name sortKey="Galimberti, Daniela" sort="Galimberti, Daniela" uniqKey="Galimberti D" first="Daniela" last="Galimberti">Daniela Galimberti</name></country><country name="Australie"><noRegion><name sortKey="Lendon, Corinne" sort="Lendon, Corinne" uniqKey="Lendon C" first="Corinne" last="Lendon">Corinne Lendon</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Asie/explor/AustralieFrV1/Data/Main/Exploration
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 007A72 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 007A72 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Wicri/Asie
|area= AustralieFrV1
|flux= Main
|étape= Exploration
|type= RBID
|clé= Pascal:10-0041243
|texte= A study of the association between the ADAM12 and SH3PXD2A (SH3MD1 ) genes and Alzheimer's disease
}}
| This area was generated with Dilib version V0.6.33. |  |